Complement mediators: key regulators of airway tissue remodeling in asthma
نویسندگان
چکیده
منابع مشابه
Mechanisms of airway remodeling in asthma.
Asthma is a chronic inflammatory disease characterized by reversible airflow limitation and airway hyperresponsiveness. Persistent inflammation in airway tissues may lead to structural changes known as airway remodeling and consequently airway obstruction that is not fully reversible and progressive loss of lung function over time. It is generally accepted that airway remodeling is closely rela...
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properties and the therapy has been shown to have an acute and sustained beneficial effect on lung function (changes in FEV 1 ) in chronic persistent asthma [6] . Antileukotrienes do not have major side effects and appear to be well tolerated by most patients [7] , but a limitation of their widespread use may be due to the large percentage of nonresponders [8] . However, for those intolerant or...
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The typical pathological features of asthma are airway remodeling and airway hyperresponsiveness (AHR). KyoT2, a negative modulator of Notch signaling, has been linked to asthma in several previous studies. However, whether KyoT2 is involved in the regulation of airway remodeling or the modulation of airway resistance in asthma is unclear. In this study, we aimed to evaluate the therapeutic pot...
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Chronic asthma is an inflammatory airways disease characterized by pathological changes in the airway smooth muscle (ASM) bundle that contribute to airway obstruction and hyperresponsiveness. Remodeling of the ASM is associated with an increased smooth muscle mass, involving components of cellular hypertrophy and hyperplasia, and changes in the phenotype of the muscle that facilitate proliferat...
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Although the etiology of varicose veins remains unknown, recent studies have focused on endothelial cell integrity and function because the endothelium regulates vessel tone and synthesizes many pro- and anti-inflammatory factors. The aim of this study was to investigate the evidence involving the endothelium in the development of varicose vein disease. In addition, tissue remodeling was invest...
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ژورنال
عنوان ژورنال: Journal of Translational Medicine
سال: 2015
ISSN: 1479-5876
DOI: 10.1186/s12967-015-0565-2